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Turning risk association to biological insight in type 2 diabetes

Following up on findings from a an earlier genome-wide association study (GWAS) of type 2 diabetes (T2D) in Latinos, researchers from the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH) traced an association detected in that study to variants in a specific gene, SLC16A11, and uncovered two distinct mechanisms by which those variants disrupt the gene's function in liver cells, possibly contributing to the pathogenesis of T2D. The findings, which appear this week in Cell, offer insights into the biology underlying T2D and suggest new leads in the search for therapeutics.........Read more